Angelica Charlotte Pickles is the main antagonist of the series. While this is so, she acts more as an antihero in the films and often sides with the babies at the end, against the films' respective main villains. She is voiced by Cheryl Chase in both Rugrats and All Grown Up!, and is among the series' original characters. She is a spoiled brat and the cousin of Tommy and Dil Pickles. In 2002, TV Guide declared Angelica Pickles 7th in their list of Top 50 Greatest Cartoon Characters of All Time. She is the arch-enemy of Tommy Pickles and the other Rugrats. Her middle name is 'Charlotte', meaning she is named after her mother, Charlotte. She claims to be 'the prettiest, most beautiful kid in the universe' (which she is). Angelica carries her favorite doll Cynthia (a parody of the popular Barbie franchise) around with her almost everywhere, and fills her room with Cynthia merchandise.
In Goanimate, she is a troublemaker who tries to get Roll Light/Selkie and her friends into trouble.
- Voice: Emma
- Likes: Anything made by Paramount and Nickelodeon
- Dislikes: Anything not made by Paramount and Nickelodeon, Roll Light/Selkie and her friends
- Fate: First, blown up by the atomic bomb with Evil Charlie and Lola. Second, sent to the nether world and getting killed by Goro and the Zombie Pigmen. Third, burned to death again with Zima, Scootatoo, Evil Lindsay, Nelson, Wolvlin, Berry the Bad, Hunter, Pablo, Tyrone, Evil Lily, Evil Zachary, Evil Bear, Jimmy Five and Smudge by Female Kana. Fourth, kidnapped by Phineas T. Ratchet and sent to the Chop Shop to be melted down for meat
- Date of death: December 25th, 2017 (But got revived by Kleines Arschloch in Kleines Arschloch revives Angelica Pickles/Beaten up by Azura)